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Moradimokhles H, Pourjamshidi M, Mozafari O. Exploring the role of blockchain technology in medical education: Future opportunities and challenges. JMED 2024; 17 (55) :138-153
URL: http://edujournal.zums.ac.ir/article-1-1889-en.html
Bu-Ali Sina University
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 Abstract
Background & Objective:
Today, blockchain technology presents a new framework that can help address some challenges facing health and medical education. Accordingly, there is a growing interest in using this important technology, especially among medical educators. Looking towards the future of educational technology and considering the end of the COVID-19 pandemic, medical education experts are expected to accept blockchain technology widely. This study aims to investigate all aspects related to the application of blockchain in medical education.
Material & Methods: The study was conducted through a PRISMA systematic review of 10 databases, namely Scopus, Web of Science, Eric, Wiley Online Library, ProQuest, Springer, Noormags, Magiran, and Irandoc, in December 2022, and was updated in February 2023. By utilizing the strategies of this systematic review, a total of 980 related articles were identified, of which 187 were selected. After screening and criteria were applied, 18 relevant articles were selected to complete the research.
Results: The results show that the application of blockchain technology in medical education has the most significant impact in the two sectors of education and healthcare. In health and treatment, blockchain technology plays a crucial role in registering patients' treatment records, storing treatment information, and ensuring the security and durability of information. In medical education, blockchain technology is utilized to issue educational certificates, enhance credibility, offer cloud storage space, and enhance the quality of teaching and learning. The trend in research methods is shifting towards mixed methods.
Conclusion: According to this study, blockchain technology in medical education creates suitable capacities for learners and teachers through a systemic approach and collective wisdom. Despite the positive aspects and efforts to address the challenges, the field of medical education is still experiencing an exponential trend in the use of technology. We expect more research and the integration of blockchain technology in medical education in the short term.


Introduction
Medical science holds a privileged position in society, encompassing various fields, with medical education being one of the most critical (1). Like other fields of education, medical education relies on various assumptions, such as experiential learning, reflective practice, and preferred teaching approaches. These assumptions have led to the adoption of competency-based education (2). Today, many unique and significant advances in medical education, including evidence-based learning, simulation, structured assessments, clinical and medical competency monitoring, and the integration of new technologies, are enhancing learning and teaching (3). Medical education is divided into primary, graduate, and continuing professional education. The ultimate goal of medical education is to cultivate a knowledgeable, skilled, and up-to-date community of healthcare professionals (4). Therefore, medical education is suitable for advancing education in academic and related organizations by utilizing new technologies (5).
On the other hand, while technology has significantly impacted many areas, such as industry, educational systems need to embrace technological advances faster. Consequently, many technologies still need to be utilized in education (6). Holon IQ, has identified four education-enhancing technologies that should receive increased spending and focus by 2025. These technologies include augmented reality, virtual reality, artificial intelligence, robotics, and blockchain (7). Blockchain is one of these technologies, semantically defined as a distributed ledger of chained and consecutive cryptographic blocks, with each block recorded in peer-to-peer networks (8). Furthermore, nodes operate similarly and are validated by other network components (9). Three eras of blockchain technology have been identified, each corresponding to the definitions of blockchain presented in that era. The current focus is on the third period of blockchain implementation and research (10).
According to Figure 1, each block in the blockchain contains essential information, including data, the block's hash, and the previous block's hash. The type of data stored in a block varies depending on the type of blockchain. For instance, a cloud blockchain used by a medical education institution stores information such as learner and instructor details, grades earned, and history. Another crucial block component is its hash, a unique human fingerprint that identifies the block and its content. When a block is created, its hash is calculated, and any changes made will result in a different hash. This feature of the blockchain makes it very secure and safe (11–12).

 
Figure 1. Blockchain structure
Blockchain technology has several key features, such as cryptographic hashing, decentralization, transparency, and verifiability (13–15). These features are repeated and configured in the elements approved by the main structure of the blockchain. Although research indicates that the utilization of blockchain technology in medical education is still in its early stages, several studies have confirmed its potential benefits. For example, research by Peters (5) found that blockchain technology in medical education offers significant benefits and can capture the attention of medical education officials towards this technology.
Another study by Tapscott et al. (28) found that a blockchain-based system for recording, crediting, and evaluating educational outcomes could be an effective method for educators to recognize the significance of their academic and systemic accomplishments. In a medical school, for instance, the curriculum can be linked to the faculty responsible for each course or block. Curriculum evaluation can be conducted within the blockchain system, which can also track the time professors dedicate to teaching, developing teaching materials, and mentoring. This approach ensures transparency for all users and leads to consensus among stakeholders.
In another study, the educational program "Blockchain," in collaboration with "Sony Global Education," provided a platform for storing the educational experiences of learners and issuing valid and official certifications (15). This platform also records informal learning activities such as competition results, internship experiences, etc., which can serve as a reference for employers and executives in organizations and universities to assess learners' abilities (16).
Implementing blockchain technology in medical education has several benefits, such as providing access to knowledge, developing models and strategies to reduce costs and improve learner experiences, standardizing curricula (17), tracking student achievements throughout the curriculum, and documenting competencies acquired through a wide range of expertise. Additionally, it can serve as a digital registration system for each participant. The research conducted so far also shows that blockchain can record the influence that instructors have on learners and can integrate with Competency-Based Medical Education (CBME) and Trusted Professional Activities (EPA) to address many of the challenges of CBME (18–19). Overall, blockchain technology is an effective method for addressing many of the challenges encountered in medical education (20).
Because blockchain technology is becoming more popular and important in medical education, and because there hasn't been any systematic review research in this area before, this study will use a systematic review method to look into how blockchain technology can be used in medical education. The researcher has agreed to explore the following questions based on the Population Intervention Comparison Outcome Time (PICOT) method by reviewing relevant studies:
1. What evidence supports the use of blockchain in medical education learning environments?
2. What methodological approaches have been used in applying blockchain to medical education learning environments?
3. What opportunities and challenges are associated with using blockchain in medical education?

Material & Methods
Design and setting(s)
For this study, we employed a systematic review approach to investigate and analyze articles on the application of blockchain technology in medical education. The systematic review, also called research synthesis, aims to present a comprehensive and unbiased summary of numerous related studies in a specific field (21). It shares many characteristics with a literature review. However, it seeks to uncover all evidence related to a query rather than focusing on concepts or theories, especially in research that reports quantitative data (22).
Participants and sampling
Search strategy
The PRISMA method (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) was utilized to conduct this systematic review. To identify relevant articles, a systematic search was conducted in seven external databases: Scopus, Web of Science, Eric, Wiley Online Library, ProQuest, Mesh, and Springer, as well as three internal databases, namely Noormags, Magiran, and Irandoc, in December 2022 and February 2023. The search was then updated. Furthermore, a manual search was conducted on Google Scholar to complement the search. The combination of two keywords, "blockchain" and "medical education," was utilized in the English database as per Table 1 and in the Persian database as per Appendix 1. These two keywords were chosen to enhance precision in identifying relevant articles, given their frequent appearance in databases and recent research on the Mesh site and other related platforms. Synonyms or other indicators were not included in the word search to improve the accuracy and quality of the research. The search used the boolean operators AND, OR, and NOT. Both OR and AND were utilized in the search term. Primary and secondary topics were precisely identified, and redundant synonyms were avoided.

Table 1. Keywords used in systematic review
OR - OR
Blockchain AND Medical education

Data collection methods
The dataset obtained from the search included articles that assessed the use of this technology in medical education environments based on specific keywords. The article selection process involved several steps. Initially, study titles were screened to determine eligibility based on predefined criteria. Subsequently, the abstracts of all primary studies were screened for eligibility using consistent criteria. Finally, the full text of the remaining articles was thoroughly examined. No restrictions were imposed on the publication date, study design, participant age, geographic location, or language. Various sources were considered, including articles from published periodicals, collections of conference articles, doctoral dissertations, and theses. However, editorials, commentaries, book chapters, and newspaper articles were excluded.
Articles that only reported the number of statistically significant studies without providing the effect size or total number of studies in a specific comparison were also excluded. The CASP checklist, a vital tool for assessing the validity of articles in systematic reviews, was utilized. Each article was evaluated for quality based on ten quality criteria, with a score between 1 and 5 assigned for each criterion. The 2018 version of the CASP checklist was utilized in this study to evaluate the validity and reliability of the qualitative analysis in the selected articles. To ensure accuracy and quality, two expert reviewers independently conducted the selection process, which included title screening, abstract screening, and full-text review. Any discrepancies among the reviewers were resolved through discussion. In cases of disagreement, the quality of articles was evaluated using "Harzing's Publish or Perish" software, which considers indicators such as h-index, g-index, hI-norm, hI-annual, and hA-index. Two evaluators analyzed and assessed conflicting articles, and a final decision was made based on their evaluation.
The output of the systematic search
The results of the systematic search depicted in Table 1 involved searching various English and Farsi databases using specific keywords and criteria. This process yielded 980 articles. The PRISMA diagram illustrates the division of the search into targeted and systematic sections. In the systematic search, 980 articles were retrieved from 11 domestic and foreign databases. Among these, 187 were identified as duplicates, resulting in 156 unique studies being screened. After reviewing the titles and abstracts, 35 articles were selected for full-text review, with 17 meeting the specified criteria. Additionally, two articles from the targeted search were included, increasing the total number of articles for the systematic review to 18. Figure 2 provides a visual representation of the study selection process. No additional records were found through alternative sources. Each phase of the selection process, including the rationale for title screening, application of the desired criteria, and final article selection for systematic review, is outlined. Five criteria were used for screening the full text of the articles: 1) Articles not relevant to the desired topic were excluded. 2) Articles that did not primarily focus on utilizing blockchain in medical education were excluded. 3) Non-journal articles were excluded. 4) Articles without online full texts were excluded. 5) The most recent study was selected in cases of duplicate first authors.The data from the selected articles for critical analysis was extracted using standard forms and input into Microsoft Excel software. All data was extracted using standardized forms, and one reviewer analyzed the data while a second reviewer confirmed its completeness and accuracy. The extracted information was categorized according to the research questions outlined in the results section. Descriptive, quantitative, and correlational techniques were employed to analyze and interpret the studies related to digital competence and professional development. Additionally, keyword analysis was used with social network analysis (24), comparative database analysis, and visualization using VOSviewer software. After defining axes, categorical thematic content analysis was done, and qualitative methods were used to condense the data and find classification clusters (25). The extracted information from the articles was organized into columns with titles such as title, objective, author, method, period, country, year of publication, and results in an Excel spreadsheet. The information from the final articles included in this systematic review was extracted and presented in standardized tables.
Data analysis
In the qualitative research evaluation, a systematic process was employed using standard forms for data extraction and Microsoft Excel for data entry to minimize bias. Three reviewers were involved in the process to ensure accuracy and completeness. The first reviewer extracted the data, and the second reviewer checked for accuracy and completeness. The data was classified according to the research questions, and a combination of quantitative and mixed qualitative article analyses was used to determine the semantic use of the desired keywords.
Kennock and Young (2008) independently reviewed studies to determine their quality. In a systematic review, bias can occur during the article selection process, and employing appropriate selection methods can significantly reduce bias. According to the selection criteria of the studies, the second reviewer evaluated the articles' title, abstract, and full text. A third reviewer analyzed and discussed any disagreements until a consensus was reached. Using the Kappa coefficient ranking statistic to assess the agreement among the reviewers in the article selection process resulted in a value of 0.698, indicating a high level of agreement between them. To enhance certainty, the Cochrane Collaboration's risk of bias tool and the Critical Appraisal Skills Program (CASP) checklist were utilized to evaluate the quality of studies and potential biases. The CASP checklist, which consists of 10 items, provided an opportunity to evaluate the quality of all selected studies (CASP Institute, 2022). The findings indicated that while all the studies were conducted well, some could be improved regarding participant selection, data collection, and data analysis.
Figure 2. PRISMA chart for the stud
Results
Three research questions accompany the research findings in this section. A four-stage perspective involving description, analysis, explanation, inference, and discussion has been utilized to elucidate the results of this analysis. Overall, the articles covered a broad scope, addressing various educational strategies, employing diverse evaluation methods, including participants of different ages and nationalities, and yielding results from different perspectives. All of these aspects will be elaborated upon in detail.
Content Analysis
Each table in the article offers distinct explanations for each section. Appendix 1 provides a comprehensive overview of the studies included in the article, with the quality column assessing the relevance of the articles based on the checklists used. Additionally, in alignment with the response to the second research question, the articles exhibited diversity in the methods employed, addressing various issues, utilizing a wide range of theoretical models, and adopting various methodological approaches. This diversity is reflected in Table 2, which categorizes the studies into quantitative, qualitative, and mixed methods. The review and experimental surveys comprised the most significant number of studies among the two categories of research methods, operational and conceptual. The number of articles mentioned for each method is based on the formula (n + 1). For instance, 15 operational articles were identified for the case study method, resulting in 16 articles based on the formula (15 + 1). Additionally, due to some studies needing to fully specify their method type and being unidentifiable upon review, an additional study has been included for each method using the formula for calculating the number of studies.
Table 2. Research methods used in the articles
Research method Practical Conceptual Number
Case Study 15 - 16
Comparative - 10 11
Content analysis - 9 10
Delphi - 6 7
Experimental 22 - 23
Mixed method 18 18 36
Fundamental - 11 12
Review 33 - 34
Survey - 17 18
Theory - 19 20
Total - - 187

Types and Fields of Study
Table 3 provides an overview of various types and fields of study. To clarify, a review encompasses all scientific literature in the field as defined by the author, while a theoretical analysis includes references essential to the analysis only.
Table 3. Concepts used in the articles
Type Practical Conceptual Number
Education 16 13 29
Arts and humanities 9 12 21
Trade and international 5 3 8
Management 2 3 5
Accounting 25 4 29
Computer science 1 5 6
Communications 6 9 15
Growth 2 1 3
Engineering, education 5 7 12
Human-computer interaction - 4 4
Librarianship and information 2 5 7
Innovation 6 1 7
Psychology 4 1 5
education 10 26 36
Total - - 187

The results indicate that the survey method is the most common type of study, followed by theoretical and case studies. While there were twelve performance assessments, most studies did not specify participants' exact skill levels and relied on self-assessment. In total, 187 studies utilized various methods such as surveys, comparative analysis, content analysis, case studies, Delphi studies, experiments, integrated methods, fundamental research, reviews, surveys, and theoretical analysis.
Thematic categories from the Scopus journal classification were used to categorize the study fields. As per the classification, it was observed that this technology has made minimal inroads in medicine and is still in its early stages, but has gained more traction in other medical fields, such as treatment and development discussions.
General Concepts
Table 4 presents an overview of the concepts discussed in the articles. Notably, the discussion of medical education has yet to be emphasized as a critical concept, with most articles not focusing on this aspect. In the studies conducted in education, coaches and trainers have been the primary focus. In contrast, other groups in education and upbringing have received less attention.
Table 4. Overview of the concepts used in the articles
Type Number
Blockchain 97
Artificial intelligence 42
Lifelong learning 19
Multiliteracy 15
Augmented Reality 14
Total 187

Target Population of the Studies
The reviewed study participants included medical and health community members, such as doctors, patients, trainers, and trainees (students). The geographic scope of the studies included Croatia, Canada, India, Germany, Switzerland, the United States, Spain, China, Norway, Taiwan, and other countries. The results can be generalized to other countries and implemented accordingly.

Discussion
As per the systematic review questions, the first addressed the evidence of blockchain use in medical education learning environments. The articles examined in this research indicate that universities and medical education institutions have adjusted their performance and operational plans, especially in the era of COVID-19. There is a growing focus on applying new technologies, such as blockchain, in medical education. While medical education has traditionally focused on treatment and increasing productivity in the health sector, there is now a noticeable interest in education and learning among students. In recent years, there has been a shift in focus toward medical education and treatment, particularly in treatment methods, patient health, medical device manufacturing, and related areas, as evidenced by studies. Since 2019 and the global spread of COVID-19, blockchain technology has gained significance in trade, commerce, the economy, and income (28–30). The application and perception of new technologies in medical education have adapted to the existing conditions and aimed at improvement, leading to fundamental changes. The third wave of blockchain technology has garnered more attention in medical education, prompting researchers, organizations, and educational institutions to explore its use, leading to significant transformations. Recent developments and applications in both the health and education sectors have highlighted the potential of blockchain technology in medical learning and education. This includes securing patient information, controlling access to patient data, storing data securely, issuing valid and non-falsifiable documents, utilizing cloud space for various purposes, ensuring easy access to content and data, establishing a scientific foundation, managing health supply chains, handling medical insurance, ensuring security in applications, and incorporating Internet of Things technologies related to health and medical education (31–33).
In response to the second question, it can be observed that, based on the diagram and the review of evidence and studies, research methodology approaches in the application of blockchain in medical education have shifted towards qualitative and mixed methods in recent years (34). The research approach of articles during COVID-19 has shown a preference for the mixed method. Additionally, survey methods are the most common type of study in this field, followed by theoretical studies and case studies. Studies aiming to expand knowledge in this field have predominantly chosen the case study method. Based on the reviews, the approach in the studies that utilize data and design based on blockchain technology to address challenges and issues shows a promising trend. It is expected that this trend will continue in the coming years (According to Figure 3).
Figure 3. Overview of the methods utilized in the articles

In the third question of this research, the opportunities and challenges of using blockchain in medical education were analyzed using Meredith and Colague's SWOT matrix. This matrix analyzes strengths, weaknesses, opportunities, and threats and is crucial for comparing information and presenting four types of strategies (35). The efficacy of a SWOT matrix analysis hinges upon an organisation’s capacity to engage its human resources in strategic planning processes (36). Moreover, this matrix has become a fundamental tool for organizations to assess their position. It is widely used for analyzing organizations' internal and external environments, including medical education, when making decisions (37, 38). This matrix outlines the four components of internal or external considerations. Firstly, strengths refer to the internal elements of the organization that distinguish it from others and contribute to its excellence. On the other hand, weaknesses are internal factors that hinder the organization's success and impede its growth process. Opportunities refer to external factors that can give the organization a competitive advantage in achieving its goals. It presents positive environmental aspects and opportunities to address gaps and initiate new activities. Conversely, threats can harm the organization, acting as obstacles or potential obstacles to achieving its goals (39, 40).
Strengths: The field of medical education has demonstrated significant interest in utilizing blockchain technology as a competitive advantage. Other strengths include the fact that resources have historically been focused on health and treatment in the medical field and related institutions. However, there is a growing emphasis on the field of medical education. This has led to advancements in security and the issuance of documents and certificates by universities and institutions.

Weaknesses: The potential for blockchain technology development is most prominent in medical education. Organizations and institutions can utilize this technology for educational purposes, such as issuing university degrees, reconciling grades and courses, and providing a private and secure space. The need for more attention to integrated educational approaches could result in adverse outcomes. The need for more resources in education-related organizations and institutions, compared to sectors like health and treatment, is evident. The trial-and-error approach to implementing blockchain technology requires significant time to establish a stable mechanism, which poses a weakness in the medical education sector.
Opportunities: Further development in this field can be achieved by utilizing blockchain-related technologies. For instance, combining various platforms for educational record storage and health professions training can enhance performance. Increased focus on the medical field can facilitate the adoption of blockchain technology, especially in the education and learning sector, serving both general and specific target communities. The experience of virtual and electronic education during the COVID-19 pandemic could create a competitive environment in medicine. Blockchain technology's accuracy, reliability, and reasonable cost offer significant opportunities, providing support and secure cloud space for resource maintenance and storage.
Threats: Privacy violations and data source manipulation pose significant threats to organizations that lack a specific mechanism for managing such issues. The ambiguity surrounding blockchain technology can also be considered a threat because it can compromise the privacy of individuals and organizations. Unclear legal responsibilities at the onset of technological implementation can pose threats. Competitors seeking to undermine the technology's security and stability for commercial and financial gain also threaten the field.
In this systematic review, 187 articles presented conceptualizations of medical education through the application of blockchain technology. This recognition indicates concerns about the need for more attention to education applications in this field. The diagnosis and treatment section was studied in more detail, revealing a predominant focus of attention in this area. Furthermore, it was observed that most existing measurement tools target learners, highlighting the need for more utilization of blockchain technology in medical education, especially within formal and informal medical education institutions.

Conclusion
In conclusion, modern technologies, including blockchain, have significantly transformed the field of medicine, particularly in medical education. Over the past few years, there has been a noticeable shift in the application of blockchain technology from the treatment and health sector to education. The various applications of this technology in medical education, such as data storage, issuance of educational certificates, enhancement of organizational security, and improvement of human resources skills and potential, signify the growing focus on this area. As with any emerging technology, blockchain has strengths, weaknesses, challenges, and opportunities. The results of surveys indicate that the progress made is primarily due to its positive aspects. The included studies confirm the potential for blockchain technology to undergo three different periods of evolution, reflecting its positive impact on medical education research. The results also highlight the substantial growth in interest in the emerging field of blockchain in medical education over the past two decades. Researchers have explored a wide range of issues, focusing on the effectiveness of specific educational methods and their application in medicine and health. The attention given to this field is increasing, and blockchain technology has proven to be a powerful tool for analyzing complex medical data and has gained popularity in medical education research. Furthermore, the use of blockchain technology in addressing challenges related to COVID-19 and its impact on the prediction, acquisition, and development of science in the medical field underscores the necessity of this technology in medicine.
In summary, blockchain technology has the potential to create significant capacities in medical education, and its systemic approach and collective wisdom are contributing to its exponential use in the medical education process. Blockchain technology will continue to be the subject of extensive research in medical education in the coming years.

Ethical considerations
All ethical principles have been observed in all stages of this article.
Artificial intelligence utilization for article writing
Artificial intelligence was not used in this study.
Acknowledgments
To all the authors who have shared their research findings on the application of blockchain technology in medical education, we extend our sincere gratitude for making it available for further exploration and research.
Conflict of interest statement
The authors reported no potential conflict of interest.
Author contributions
H. Moradimokhles and M. Pourjamshidi were responsible for designing the study and supervising the study. O. Mozafari did the final review of the articles, and M.Yenkimaleki did the literary editing and implementation of the Journal format.
Supporting resources
Bu-Ali Sina University, Hamedan, Iran, supported this research financially.
Data availability statement
This research is a systematic review that does not have specific underlying data.



  
Article Type : Review | Subject: Medical Education
Received: 2023/03/16 | Accepted: 2024/04/2 | Published: 2024/09/10

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