Background & Objectives: Entrepreneurship and enhancing entrepreneurial activities can be considered as an appropriate stimulus for the growth and development of communities and also for increasing the income and finally for improving people lives. The present study was done to evaluate the entrepreneurship spirit of students in Kurdistan and Kermanshah Universities of Medical Sciences, 2015-2016.

Material and Methods: This was a cross-sectional study. The populations of the study  were Kurdistan and Kermanshah Universities of Medical Sciences, the  students, of which  were 500 who selected by classified random sampling using a proportional allocation. A questionnaire including 45 items was used to collect data on entrepreneurial spirit. In order to describe and analyze the collected data  the descriptive statistics including frequency, mean, standard deviation and Mann-Whitney U and Kruskal-Wallis was used.

Results: The mean score of entrepreneurship among studied students was equal to 29.69±5.07. The scores in Kurdistan University of Medical Sciences students and Kermanshah University of Medical Sciences students were 29.89±5.13 and 29.52±5.03 respectively. The Entrepreneurial spirit between the two universities, did not show  statistically  a significant difference (P=0.98).

Conclusion: The results of the present study showed that students of both universities in most areas of the entrepreneurial spirit had high entrepreneurial spirit (above average). This can be a favorable ground for implementing programs related to the development and entrepreneurship training.