en علوم پزشکی Medical Sciences پژوهشي اصیل Orginal Research <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="line-height:2;"><span style="font-size:10pt"><b><span style="font-size:12.0pt"><span style="color:black">Background & Objective</span></span></b><span style="font-size:12.0pt"><span style="color:black">: Perceived awareness and concern for mental health issues among students in Indonesia are still lacking, proceeding before and during the coronavirus disease 2019 (COVID-19) pandemic. In order to gain future benefits, this study evaluates pre-clinical medical students&#39; mental health during the first year of the COVID-19 pandemic in Indonesia.</span></span></span><br> <span style="font-size:10pt"><b><span style="font-size:12.0pt"><span style="color:black">Materials & Methods:</span></span></b><span style="font-size:12.0pt"><span style="color:black"> This cross-sectional study was conducted on pre-clinical medical students at the Faculty of Medicine, Universitas Islam Indonesia (FM UII), Yogyakarta, Indonesia, in April 2021. A total sampling method was employed. Participants completed online self-reported questionnaires, including socio-demographic data and the Depression, Anxiety, and Stress Scale-21 (DASS-21) questionnaire to evaluate mental health. Descriptive, bivariate, and multivariate analysis was performed.</span></span></span><br> <span style="font-size:10pt"><b><span style="font-size:12.0pt"><span style="color:black">Results: </span></span></b><span style="font-size:12.0pt"><span style="color:black">A total of 273 pre-clinical medical students were included in this study. They</span></span><span style="font-size:12.0pt"> suffered from depression (35.2%) and stress (40.3%) more than a third and about half suffered from anxiety (50.2%). Females were more likely to have depression (AOR: 2.22; 95%CI: 1.19 to 4.15), anxiety (2.56; 1.42 to 4.61)</span><span style="font-size:12.0pt">, and stress (3.44; 1.81 to 6.54) than males. Anxiety was less common in medical students in their second </span><span style="font-size:12.0pt">(0.48; 0.23 to 0.98) and third (0.29; 0.13 to 0.67) years than in the first year. Being a third-year student was a protective factor for stress (0.38; 0.17 to 0.87).</span></span><br> <span style="font-size:10pt"><b><span style="font-size:12.0pt">Conclusion:</span></b><span style="font-size:12.0pt"> A high prevalence of depression, anxiety, and stress among pre-clinical students was observed. This study can become a reflection for educational institutions and policymakers to prepare good strategies to maintain pre-clinical students&rsquo; quality and mental health <span style="color:black">during and after COVID-19 pandemic</span>. </span></span></span></span><br> &nbsp;</div> anxiety, COVID-19, depression, mental health, stress 36 43 http://edujournal.zums.ac.ir/browse.php?a_code=A-12-1938-1&slc_lang=en&sid=1 Naufal Arif Ismail naufalarifismail@gmail.com 5300319475328460023696 5300319475328460023696 Yes Faculty of Medicine, Universitas Islam Indonesia, Yogyakarta, Indonesia Nur Aisyah Jamil n.aisyah.j@uii.ac.id 5300319475328460023697 5300319475328460023697 No Department of Public Health, Faculty of Medicine, Universitas Islam Indonesia, Yogyakarta, Indonesia